Chronically stressed? It may be caused by a gut dysbiosis. Try restoring your Lactobacillus levels!
Inhibiting the enzyme called Glyoxalase 1 (GLO1) relieved signs of depression in mice in 5 days (Prozac takes 14). This inhibition also seems to alleviate anxiety in mice but not in humans so the anti-depression-effect could be just for mice, too!
Caution: GLO1 is responsible for the detoxification of the glycolytic byproduct methylglyoxal (MG) which is a cytotoxin and a competitive partial agonist at GABA-A receptors (e. g. movement control, sleep initiation + maintenance). MG is highly reactive and induces the formation of advanced glycation end-products (AGE) which causes aging (yeah, funny scientists at work) and is present in cancer patients. MG is not something you want in your body in excess! In a cancer study the scientists detected a high level of MG adducts and low GLO1 activity in high stage tumors compared to low stage ones! GLO1 depletion promoted tumor growth!
I really wouldn’t want to trade depression against cancer…cut out the sugar and you will reduce the glycolysis which should reduce MG and therefore GLO1!
Posts I really loved:
Why We’re a Culture of Addicts
The theory here is that addicts are in pain because of childhood loss or trauma which impairs brain circuitry. The brain can’t produce enough endorphins (which should create a feel-good-sensation) and the reward-centered dopamine so that it’s on a neverending search to trigger them!
“A brain that experiences the first rush of heroin as a “warm, soft hug,” as a 27-year-old sex trade worker described it to Maté.”
Addicts don’t choose their addiction. They actually have not much of a choice because of this rather unconscious mechanism. We have to get to know our addiction triggers or else we won’t stand a chance against our own addictive behaviour. And addiction isn’t just alcohol or drug abuse – it could be something like shopping or food addiction!
“We lack compassion for the addict precisely because we are addicted ourselves in ways we don’t want to accept and because we lack self-compassion. – Gabor Maté” (upliftconnect.com)